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KMID : 0931320140140040288
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대한상부위장관.헬리코박터학회지
2014 Volume.14 No. 4 p.288 ~ p.291
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A Case of Pediatric Menetrier’s Disease Associated with Helicobacter pylori Infection
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Yoon Ji-Hong
Ahn Moon-Bae
Maeng Lee-So
Kim Sang-Yong
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Abstract
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Menetrier’s disease in childhood is a rare form of gastropathy characterized by hypoalbuminemia, endoscopic and/or radiologicfindings of hypertrophic gastric folds, and histologic findings of foveolar hyperplasia in the stomach. It tends to have a self-limitedcourse compared to the chronic and complicated course in adult Menetrier’s disease. A 7-year-old boy was referred to Incheon St.Mary’s Hospital for facial edema. Physical examination on admission showed periorbital swelling, pitting edema in both legs, andepigastric tenderness. Laboratory tests on admission indicated hypoproteinemia (3.0 g/dL) with hypoalbuminemia (2.1 g/dL) andhypogammaglobulinemia. Urinalysis showed no abnormalities. The test results for anti-cytomegalovirus immunoglobulin M andcytomegalovirus PCR were negative. Stool Helicobacter pylori antigen was positive and fecal α1-antitrypsin clearance was 40.1mL/day, consistent with protein-losing gastroenteropathy. Gastroduodenoscopy showed hypertrophic edematous gastric folds, erythema,and superficial erosion in the body of the stomach. The duodenum was normal. Histologic findings showed foveolarhyperplasia. His symptoms improved with conservative treatment including proton pump inhibitor from day 9 of hospitalizationand resolved completely. Here we reported a case of pediatric protein-losing hypertrophic gastropathy associated with Helicobacterpylori infection.
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KEYWORD
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Helicobacter pylori infection, Protein-losing gastropathy, Menetrier’s disease
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